The Effects of Body Weight and Combination Drug Therapy on the Serum Concentrations of Zonisamide in 94 Epileptic dogs: An Epidemiological Analysis
نویسنده
چکیده
To clarify the effects of background factors such as body weight, combination drug therapy with phenobarbital (PB) and potassium bromide (KBr), age, gender, neuter status, and blood collection time on the serum concentrations of zonisamide (ZNS) in 94 epileptic dogs, serum ZNS concentrations of 141 samples from 94 epileptic dogs were measured by high-performance liquid chromatography with UV detection. Serum ZNS concentrations were divided by the dosage of ZNS, to obtain normalized ZNS concentrations. Multiple linear regression analysis revealed that body weight and combination therapies with KBr, PB, and KBr + PB affected the normalized ZNS concentrations, and normalized ZNS concentrations The Effects of Body Weight and Combination Drug Therapy on the Serum Concentrations of Zonisamide in 94 Epileptic dogs: An Epidemiological Analysis Koya Fukunaga1 DVM, PhD
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